【单选题】An individual has been diagnosed with hereditary diffuse type stomach cancer, in which rather than being located in one area of the stomach, the tumor is located in many areas of the stomach. A mutation in which one of the following proteins would lead to such a disorder?
选项：

A:P5.3. protein
B:NF-1.
C:Rb gene
D:Cadherins
E:Caspases